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Dr Leila Roshangar

Research Interest:          

At this moment, the field of regenerative medicine is highly considered in clinics. Our goal, in regenerative medicine, targets the application of isolated cells from different organs, such as cartilage, fibroblast, etc.

Our main aim is to provide new techniques for treatment of degenerative diseases especially osteoarthritis as well as cutaneous reconstitution. In line with this purpose, the isolated cells from the different tissue sources or in vitro-prepared engineered tissues are utilized. In the field of osteoarthritis, the chondrocytes, from experimental animals and arthritic patients, are expanded in vitro and the effect of different factors and scaffolds on their proliferation and metabolic functions are further examined. Another point of our interest is to prevent dedifferentiation of transplanted chondrocytes. For which, the methods of transplanting and fixing the engineered tissue are examined in experimental models. The second point is to induce stem cells differentiation to chondrocytes. Stem cells with different origin, including fat-derived stem cells, cord blood-derived stem cells and mesenchymal stem cells are being investigated. In addition, extracellular matrix formations by fibroblasts or stem cells, tissue-engineering substitutes and the effect of different inhibitory and enhancing factors are investigated in vitro. 

 

Research Focus:

1.  Regeneration articular cartilage

 

Group members:

1-      Vahedee  Parviz, PhD student

2-      Parisa Nikpoo,  PhD student

3-      Zynab Salehei, MSc student

4-      Sepideh Hassanpoor, PhD student

5-      Shahnaz Sabetkam, PhD student

 

Publications:                                                                                        

Roshangar L, Hamdi BA, Khaki AA, Rad JS, Soleimani-Rad S. Effect of low-frequency electromagnetic field exposure on oocyte differentiation and follicular development. Advance Biomedical Research. 2014 (27); 3:76.

Heidari R, Babaei H, Roshangar L, Eghbal MA. Effects of enzyme induction and/or glutathione depletion on methimazole-induced hepatotoxicity in mice and the protective role of N-acetylcysteine. Advanced Pharmaceutical Bulletin. 2014; 4(1):21-28.

Roshangar L, Abdollahifard S, Majdi A, Zarrintan A, Ghasemzade A, Farzadi L, Soleimani Rad S, Soleimani Rad J.Study of ultrastructure and apoptosis in the endometrium of women with or without endometriosis. Iranian Journal of Reproductive Medicine. 2013; 11(5): 399-404.

Roshangar L, Soleimani-Rad J, Rashedee B, Mazochian H, Nikzad B, Soleimani Rad S.Ultrastructural and morphometrical study of preimplantation endometrium in superovulated mice treated with progesterone or Sildenafil. Iranian Journal of Reproductive Medicine. 2013; 11(10):807-814.

Hosseinchi M, soltanalinejad F, Najafei G, Roshangar L. Effect of Gibberellic acid on the quality of sperm and in vitro fertilization in adult male rats. Veterinary Research Forum. 2013; Available Online from 15 December 2013.

Teimouri F, Khaki AA. Roshangar L. Effect of electromagnetic fields on apoptotic cells in hippocampus mithochondria of rat by TUNEL method. World of Sciences Journal. 2013; (1) 8, 1-5.

Ferdosi A, Bakhtiari M, Soleimani Rad J, Roshangar L, Jameie B.Study of the effect of exogenous melatonin on sperm fertility in busulfan induced oligospermic of pinealectomeized rat. Razi Journal of Medical Sciences. 2013; 20 (110).

Ferdosi A, Bakhtiari M, Soleimani Rad J, Roshangar L, Jameie B. Study of the effect of exogenous melatonin on spermatogenesis in busulfan induced oligospermic of pinealectomeized rat. Journal of Kermanshah University of Medical Sciences. 2013; 16 (6).

Sadeghzadeh Oskouei B, Ganbari AA, Roshangar L, Khaki AA, Soleimani Rad J. The effect ofamlodipine administration and in vitro addition of pentoxifylline on sperm parameters in mice. Journal of Tabriz University of Medical Sciences 2012; 33(6); 16.

Montaseri A, Roshangar L, Soleimani Rad J, Shafaei H, Shakibaei M, Jarolmasged H, Navali AM. Formation of repaired hyaline cartilage using PDGF-treated chondrocyte/PCL construct in rabbit knee articular cartilage defect. Annals of Biological Research. 2012, 3 (4):1975-1986.

Hamdi AB, Soleimani Rad J, Khaki AA, Roshangr L. Pathology of testis in newborn mice Exposed to electromagnetic field during developmental period. Advances in Environmental Biology. 2011; 5(10):3230.

Hamdi AB, Roshangr L, Khaki AA, Soleimani Rad J. Histological study of testes and sperm parameters in adult mice exposed to 50 Hz electromagnetic field during development. Annals of Biological Research. 2011; 2(5):455-462.

Rashidi B, Soleimani Rad JI, Roshangar L, Alizadeh Miran R. Evaluation of pinopodes expression on the mouse endometrium immediately before implantation by treatment with HMG/HCG and sildenafil citrate administration. Iranian Journal of Basic Medical Sciences. 2012; 15(5):1091-1096.

Babaei H, Roshangar L, Sakhaee E, Abshenas J, Kheirandish R, Dehghani R. Ultrastructural and morphometrical changes of mice ovaries following experimentally induced copper poisoning. Iran Red Crescent Medical Journal. 2012; 14(9): 558-568.

Rashidi B, Rad JS, Roshangar L, Miran RA. Progesterone and ovarian stimulation control endometrial pinopode expression before implantation in mice. Pathophysiology. 2012; 19(2):131-135.

Maleki N, Roshangar L, Khaki AA, Soleimani Rad J. Effect of estrogen on spermatogonic disorders induced by cyclophosmaide in mice. Pharmaceutical Sciences. 2012; 17(4): 243-252.

Roshangar B, Soleimani-Rad J, Ansaree R, Roshangar L. Effect of low frequency Electromagnetic Field on cardiovascular system: An ultrastructural and immunohistochemical study. Annals of Biological Research. 2012, 3 (1):81-87.

Sayyah-Melli M, Kazemi-Shishvan M, Soleimani-Rad J, Rashidi MR, Roshangar L, Rashtchizadeh N, Ouladesahebmadarek E, Ghojazadeh M and Mashrabi  O. The ovario-protective effect of erythropoietin against oxidative damage associated with reperfusion following ovarian torsion in rat. American Journal of Animal and Veterinary Sciences. 2011; 6(1): 18-24.

Hassan pour S¸ Roshangar L, Soleimani Rad J. Fertilization capacity of ovum in mice exposed to tamoxifen during embryonic development. Pharmaceutical Sciences 17(1): 43-48.

Ebrahimi- kalanA, Soleimani Rad J, Roshangar L, Khaki AA, Mohammadnejad D. Effect of ginsenoside as a phytoestrogen on busulfan-induced disorders in semen parameter. Pharmaceutical Sciences. 2011; 17(1): 27-34.

Asvadi I, Hajipour B, Asvadi A, Asl NA, Roshangar L, Khodadadi A. Protective effect of pentoxyfilline in renal toxicity after methotrexate administration. Eur Rev Med Pharmacol Sci. 2011; 15(9):1003-1009.

Asadpoor SH, Soleimani rad J, khaki AA, Roshangar L. The effect of oxidative stress produced by buthionine sulfoximine induced reduction of glutathione on development of testis and semen parameters in mice. Medical Journal of Tabriz University of Medical Sciences 2011; 33(4); 7.

Hassanzadeh K, Roshangar L, Habibi-asl B, Farajnia S, Izadpanah E, Nemati M, Arasteh M, Mohammadi S. Riluzole prevents morphine-induced apoptosis in rat cerebral cortex. Pharmacological Reports. 2011; 63(3): 697-707.

Farnam A, Fakhari A, Roshangar L, Kahni S, Farhang S. Planning genomic study in an animal model of depression: a preliminary report. Bioimpacts. 2011; 1(3): 179-81.

Roshangar L, Zarrintan A, soleimani rad J. Morphological and Histological detection of proliferating cells in oovarian follicle induced by anticancer drug study. International Journal of Fertility and Sterility (UFS). 2011; 5 (sup 1).

Hajebrahimi S, Roshangar L, Mohajery D, Zeynali M, Mesgari M. Histopathological effects of mid- urethral tapes: An animal study on female rats. Agricultural Journal. 6(4): 181-187, 2011.

Dianat V, Farhoodi M, soleimani Rad J, Roshangar L, Study the effect of vitrification on connection between cumulus cells and oocytes and its relationship with oocytes growth in mice. Annals of Biological Research. 2011; 2(40): 174-179.

Modaresi Esfeh J , Ostadrahimi A, Somi MH, Roshangar L, Pourghassem B, Halimi H. The relationship between helicobacter pylori infection and dietary habits. Behbood Journal 2011; 15(2): 186-192 .

Javadi L, Pezeshkian M, Afrasiabi A, Garjani A, Roshangar L, Golmohammadi Z, Nouri M. Erythropoietin prevention effect on induced apoptosis by ischemia reperfusion in myocytes in rat. Journal of Cardiovascular Thoracic Research. 2010, 1-7.

Hassanzadeh K, Habibi-asl B, Roshangar L, Nemati M, Ansarin M, Farajnia S. Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar region of the rat spinal cord. Pharmacological Reports. 2010; 62(4): 664-73.

Hassanzadeh K, Habibi-asl B, Farajnia S, Roshangar L. Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance. Neurotoxicity Research. 2011; 19(4): 649-59.

Roshangar L, Rad JS, Afsordeh K. Maternal tamoxifen treatment alters oocyte differentiation in the neonatal mice: inhibition of oocyte development and decreased folliculogenesis. Journal of Obstetrics and Gynecology Research. 2010; 36(2):224-31.

Shahi S, Rahimi S, Yavari HR, Mokhtari H, Roshangar L, Abasi MM, Sattari S, Abdolrahimi M. Effect of mineral trioxide aggregates and Portland cements on inflammatory cells. Journal of Endodontics. 2010; 36(5): 899-903.

Nejad D, Rad J, Roshangar L, Karimipor M, Ghanbari AA, Azami A, Valilu A. A study on the effect of thiotepa on mice spermatogenesis using light and electronic microscope. Pakistan Journal of Biological Sciences. 2008; 11(15): 1929-1934.

Rashidi B, Roshangar L, Soleimani Rad J, Khaki AA, Mohammadnejad D, Azami I: Comparison of morphology and morphometry of preimplantation mouse uterine endometrium in natural cycle with those received superovulatory drugs, progesterone and sildenafil citrate. Pharmaceutical Sciences. 2008; (3);33-39.

Ghaffari T, Nouri M, Rashidi MR, Vatankhah AM, Rezazadeh H, Roshangar L: Inhibition of streptozotocin-induced oxidative stress by vitamin E and selenium supplementation in diabetic rats. Pharmaceutical Sciences. 2009; 15 (3): 269-278.


Yavari HR, Shahi SH, Rahimi S,shakouie S, Roshangar L, Mesgari M, Sattari Khavas S: Connective tissue reaction to white and gray MTA mixed with distilled water or chlorhexidine in rats. Iranian Endodotic Journal. 2009; 4(1): 25–30.

Razeghi S, Arefhosseini R, Ebrahimi M, Togha M, Roshangar L, Tarihi T. Prevention of Animal Model of Multiple Sclerosis by oral genistein, extracted from soy bean. Iranian Journal of Neurology. 2009; (7)26: 505-517.

Sohrabi M, Soleimani J, Roshangar L, Vatansever S, Arbabi F, Khaki AA, Abbasi MM, Dustar Y, Javadzadeh Y. The effect of dietary and topical celecoxib on 4-nitroquinoline-1-oxide-induced lingual epithelium alternations in rat. Journal of the Pakistan Medical Association. 2009; 59(11): 769-774.

Sohrabi M, Kalati FA, Vatansever S, Abbasi MM, Roshangar L, Khaki AA, Tuglu IM, Aydemir I, Dustar Y, Javadzadeh BY, Rad JS. Effect of dietary and topical Celecoxib on expression of bcl-2, bax, c-erb-B2 and Ki67 in carcinogen-induced tongue carcinoma in rat. Pakistan Journal of Biological Sciences. 2009; 15(10): 750-757.

Kheradmand A, Roshangar L, Taati M, Sirotkin AV. Morphometrical and intracellular changes in rat ovaries following chronic administration of ghrelin. Tissue and Cell 2009; 41(5):311-317.

Roshangar L, Soleimani Rad J, Nikpoo P, Sayyah melli M: The effect of oxytocin injection on folliculogenesis, ovulation and endometrial growth. Iranian Journal of Reproductive Medicine 2009; 7(2) 91-95.

 

Naderpour M, Rad JS, Ayat E, Mesgari M, Farahani RM, Roshangar L, Tubbs RS, Shoja MM.Dietary L-arginine and cutaneous wound healing. The Italian Journal of Anatomy and Embryology. 2008; 113(3):135-142.

Yavari HR, Shahi S, Rahimi S, Shakouie S, Roshangar L, Mesgari Abassi M, Sattari Khavas S.Connective Tissue reaction to white and gray MTA mixed with distilled water or chlorhexidine in rats. Iran Endod J. 2009; 4(1): 25-30.

Kheradmand A, Roshangar L, Taati M. The role of ghrelin on the morphometry and intracellular changes in the rat testis. Tissue and Cell 2009; 41(2):105-111.

Shokouhi G, Tubbs RS, Shoja MM, Roshangar L, Mesgari M, Ghorbanihaghjo A, Ahmadi N, Sheikhzadeh F, Rad JS. The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. Life Sciences. 2008; 82 (15-16): 840-846.

Asl NA, Sheikhzade F, Torchi M, Roshangar L, Khamnei S. Long-term regular exercise promotes memory and learning in young but not in older rats. Pathophysiology 2008; 15(1): 9-12.

Shokouhi G, Tubbs RS, Shoja MM, Hadidchi S, Ghorbanihaghjo A, Roshangar L, Farahani RM, Mesgari M, Oakes WJ. Neuroprotective effects of high-dose versus low-dose melatonin after blunt sciatic nerve injury. Child's Nervous System. 2008; 24(1):111-117.

Roushangar L, Rad JS. Ultrastructural alterations and occurrence of apoptosis in developing follicles exposed to low frequency electromagnetic field in rat ovary. Pak J Biol Sci. 2007; 10(24): 4413-4419.

Lafzi A, Farahani RM, Tubbs RS, Roushangar L, Shoja MM. Enamel matrix derivative Emdogain as an adjuvant for a laterally-positioned flap in the treatment of gingival recession: an electron microscopic appraisal. Folia Morphologica. 2007; 66 (2):100-103.

Soleimani Rad J, Roushangar L, Shirzadi P: The Effect of Electromagnetic Field on ultrastructure of semen producing organs, The Journal of Urmia University of  Medical Sciences. 2007; 18(2); 504-510.